First 30 minutes
Redeem every active code (NewTrait, NewMutation, Mega, BonVoyage), finish the starter island quest chain, and pick up the Bloodline NPC slot. Save the Miracle Birth Fruit and Gorgeous Fruit.
First Bloodline slot
Lock in Milofoy or Picomori if you roll either early. Avoid spending rerolls on Snowbloom or Serpent Deity unless you are already at the slot-2 unlock at Level 7.
When to spend fruit
Save Miracle Birth Fruit and Gorgeous Fruit until you have a Dark Hiller, Milofoy, or Verdantstag candidate. Spending on C-tier Seedmon or Flowermon is the most common mistake.